Formulation and in Vitro Evaluation of Rapidly Disintegrating Tablets Using Captopril as a Model Drug

The present study was aimed towards the formulation and in vitro evaluation of rapidly disintegrating tablets by direct compression technology using Captopril as a model drug. Rapidly disintegrating tablet of Captopril was formulated using three Superdisintegrants in different concentrations i.e. 4%w/w, 8%w/w and 12%w/w and one disintegrants having concentration i.e. 2% w/w/, 4% w/w and 6% w/w like Croscarmellose sodium, Crospovidone, Sodium Starch Glycolate and Indion 414. All the batches were prepared by direct compression method using the Cadmach Single punch tablet compression machine using 8 mm flat punch. Disintegration time and drug release were taken as the basis to optimize the immediate release tablet. Prepared tablets were evaluated for thickness, hardness, friability, uniformity of weight, disintegration time, wetting time and dissolution study. Crospovidone in the concentration of 12 % gives fasted disintegration in 22 sec. and shows and 80% drug release in 10 min at gastric pH is selected as the optimized formulation. Selected formulation was subjected to stability studies for thirty days which showed stability with regards to release pattern.